|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
K
|
|
BRENDA:
BR51745
KEGG:
R08517
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> 17alpha-hydroxypregnenolone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
K
|
|
BRENDA:
BS427508
KEGG:
R03783
|
|
|
|
17alpha-hydroxypregnenolone + NAD+ <=> 17alpha-hydroxyprogesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
|
KEGG:
R03327
|
|
|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> 17alpha,21-Dihydroxypregnenolone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
|
KEGG:
R04675
|
|
|
|
17alpha,20alpha-dihydroxycholesterol + 2 O2 + 4 H+ + 4 reduced_ferredoxin <=> 17alpha-hydroxypregnenolone + 4-Methylpentanal + 3 H2O + 4 oxidized_ferredoxin
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
K
|
|
KEGG:
R04676
|
|
|
|
pregnenolone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 17alpha-hydroxypregnenolone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN66-340
|
|
|
|
17alpha-hydroxypregnenolone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> dehydroepiandrosterone + acetate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
M
|
|
MetaCyc:
RXN66-341
|
|
|
|
17alpha-hydroxypregnenolone + NAD+ <=> NADH + H+ + pregn-5-ene-3,20-dione-17-ol
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
M
|
|
MetaCyc:
RXN66-350
|
|
|
|
Cholesterol_sulfate + reduced_adrenodoxin + O2 <=> pregnenolone_sulfate + 17alpha-hydroxypregnenolone + dehydroepiandrosterone_3-sulfate + oxidized_ferredoxin + H2O
|
1.14.15.6
cholesterol monooxygenase (side-chain-cleaving)
|
–
|
|
|
BRENDA:
BS186791
|
|
|
|
pregnenolone + reduced_acceptor + O2 <=> 17alpha-hydroxypregnenolone + oxidized_acceptor + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS415730
|
|
|
|
pregnenolone + reduced_acceptor + O2 <=> 17alpha-hydroxypregnenolone + A + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
|
|
BRENDA:
BS258004
|
|
|
|
17alpha-hydroxypregnenolone + NAD+ <=> 17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
|
|
BRENDA:
BS257031-a
|
|
|
|
17alpha-hydroxypregnenolone + NADH + H+ <=> 17alpha-hydroxyprogesterone + NAD+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS425314
|
|
|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS436714
|
|
|
|
17alpha-hydroxypregnenolone + reduced_acceptor + O2 <=> dehydroepiandrosterone + acetate + A + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS415535
|
|
|
|
17alpha-hydroxypregnenolone + NADP+ <=> 17alpha-hydroxy-pregn-5-en-3,20-dione + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
|
|
BRENDA:
BS257031
|
|
|
|
3beta,17alpha,20alpha-Trihydroxypregn-5-ene + NADP+ <=> 17alpha-hydroxypregnenolone + NADPH
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188347
|
|
|
|
17alpha-hydroxypregnenolone + NADPH <=> 3beta,17alpha,20beta-Trihydroxypregn-5-ene + NADP+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS188328
|
|
|
|
3''-phosphoadenylylsulfate + 17alpha-hydroxypregnenolone <=> adenosine_3'',5''-bisphosphate + 17alpha-hydroxypregnenolone_sulfate
|
2.8.2.2
alcohol sulfotransferase
|
–
|
|
|
BRENDA:
BS360334
|
|
|
|
17alpha-hydroxypregnenolone <=> dehydroepiandrosterone + acetaldehyde
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS1752
|
|
|
|
NADPH + 17alpha-hydroxypregnenolone <=> dehydroepiandrosterone + NADP+
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
SABIO-RK:
7634
|
|
|
|
NADPH + O2 + pregnenolone <=> 17alpha-hydroxypregnenolone + NADP+ + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
SABIO-RK:
7672
|
|